People usually consume alcohol to get high, but what if the human body itself produces chemicals? Recently, the rare phenomenon was reported in Europe’s Belgium, where a man was arrested in a drunk-and-driving case. He has been cleared of charges due to a rare medical condition called auto-brewery syndrome (ABS). Another coincidence that adds intrigue to the man’s narrative is that he works in a brewery. To confirm, officials performed three independent medical investigations of Anse Ghesquiere to get the proper diagnosis of ABS. During the hearing, the judge noted that Ghesquiere did not showcase any signs of intoxication during the traffic stop.
What is Auto-Brewery Syndrome?
According to Dr Manish K Tomar, who is a consultant gastroenterologist and hepatologist at Yatharth Hospital, Gut Fermentation Syndrome (GFS) – also known as Auto-Brewery Syndrome – is classified as a rare condition in which the individual’s body produces ethanol in its gastrointestinal tract. The body turns carbs into alcohol via fermentation by bacteria in the GI tract.
Who does ABS affect?
According to reports, the rare condition can affect any gender or any age. The condition is more common in people dealing with another disease called diabetes, obesity, or conditions that affect the immune system or gut health.
Studies suggest that individuals with genetic polymorphisms in ADH (alcohol dehydrogenase) and ALDH (aldehyde dehydrogenase) may have a more difficult time metabolising ethanol, which might exacerbate alcohol intoxication symptoms.
Dr Tomar further stated that the interaction between the ADH and ALDH genes, as well as their polymorphisms, might contribute to the severity and development of ABS. ABS is a condition in adults that arises due to an overgrowth or imbalance of certain fermentation-promoting microorganisms in the small intestine, notably yeasts like Saccharomyces cerevisiae.
According to Dr Tomar, this abnormal microbial scenario transforms dietary carbohydrates into ethanol, leading to intoxication-like effects.
Signs and symptoms:
The symptoms of this disorder can be quite similar to the signs of alcohol intoxication. One might observe an increase in blood alcohol content leading to slurred speech and confusion, as well as a notable flush in the skin. Those affected by this condition might also deal with bothersome digestive problems such as bloating, excessive gassiness, and frequent diarrhoea.
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