Preparing for the fight
What weapon's the best? Magnums and shotguns over sub-machine guns and pistols is the way to go. For Wesker, a rocket launcher is the best (and expensive) way to end fights. For knocking out Jill, a grenade launcher with flash grenades is the best option.
First aid/herbs. You should have at least 3 first aid/herbs for each partner.
First encounter
You must flee the area. As of right now, Wesker has the advantage of Jill providing gun fire for him. To negate this effect, run to the right side of your starting position and head for the blue door. Stay behind the column by the door to avoid Jill's gunshots. If playing co-op, one partner should shoot Wesker to draw attention away. The partner in cover should shoot Jill with the flash rounds in the grenade launcher.
A cutscene should play. When it ends, Chris should turn around and head up the stairs and into a hallway. As Chris, take cover at the end of the hallway and wait until Wesker comes. Then, shoot him quickly as many times as possible. As Sheva, wait for the above situation to unfold by hiding behind a column. Then when Chris starts shooting Wesker, head up into the hallway he's in and then shoot Wesker from behind while he fights Chris.
At this point, he either dashes toward you or he's dazed. If he dashes then run away and repeat step 2. If he is stunned then run up to him and complete the quick time event.
Repeat the above.
You could also buy the rocket launcher. Shooting him while he holds the rocket instantly ends the fight. Make sure he fights the person not holding the rocket launcher so it's easier that way.
2nd encounter
Run to each spotlight in the area. Then, turn them off. They're in the corner of the map.
When all lights are off, run away from Wesker. A cutscene should play.
Take out a rocket launcher, and shoot him while he doesn't notice you. Shoot the rocket and the fight is over.
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