Stockholm: Americans Andrew Z Fire and Craig C Mello won the Nobel Prize in physiology or medicine for their work in controlling the flow of genetic information.
The Karolinska Institute in Stockholm honoured the pair on Monday for their discovery of "RNA interference – gene silencing by double-stranded RNA."
RNA interference occurs in plants, animals, and humans. The institute said it is of great importance for the regulation of gene expression, participates in defense against viral infections, and keeps jumping genes under control.
RNA interference is already being widely used in basic science as a method to study the function of genes and it may lead to novel therapies in the future.
Fire, of the Massachusetts Institute of Technology, and Mello, of Harvard University, were born in 1959 and 1960, respectively.
"This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information. Our genome operates by sending instructions for the manufacture of proteins from DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm.
These instructions are conveyed by messenger RNA," the institute said.
Fire and Mello published their discovery of a mechanism that can degrade mRNA from a specific gene in 1998. Last year's medicine prize went to Australians Barry
J Marshall and Robin Warren for discovering that bacteria, not stress, causes ulcers.
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